By Norman Maclean
This booklet is set transgenic animals--animals into which new genes were artificially brought. It has chapters by means of best professionals at the current state-of-play in regards to the program of the transgenic expertise to diversified animal teams. Scientists have carried out experiments on an exceptional diversity of animal kinds, starting from protozoan cells, via nematode worms and fruit flies to many larger vertebrates, and this booklet offers an in-depth, up to date, finished and authoritative account of the paintings with all such animal varieties. The most probably effect of transgenic animals at the way forward for agriculture and drugs is particularly nice. those animals supply an unmatched experimental process for the examine of gene law, genetic elements of sickness, and gene treatment. one of many targets of the booklet is consequently to set transgenic animals within the context in their current and destiny contributions to technological know-how and drugs.
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Extra resources for Animals with Novel Genes
Clearly, however, the study of transposable genetic elements, and in particular the P element, has done much to advance the cause of insect molecular genetics. 2 Germ-line transformation In essence, the procedure now routinely employed in Drosophila is a simple one. The cloned gene of interest is incorporated into a transformation vector, which carries a mobilization P element sequence. This resulting plasmid is then introduced into a preblastoderm-stage embryo of an appropriate host strain. DNA is introduced by microinjection into the posterior of the embryo prior to, and at the site of, pole cell formation.
24, 543-78. Sippel, A. , Hecht, A. & Bonifer, C. (1992). The regulatory domain organization of eukanjotic genomes: Implications for stable gene transfer, in Transgenic Animals, ed. F. Grosveld & G. Kollias, pp. 1-26. London: Academic Press. Trends in Biotechnology. (1993). 11 (5), 156-215. Special volume devoted to gene therapy. Ulmer, J. B. et al. (1993). Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-9. Valerio, D. (1992). Retrovirus vectors for gene therapy procedures.
Gershon, D. (1991). Cancer trial starts. Nature 349, 445. Golic, K. G. & Linquist, S. (1989). The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59, 499-509. 20 Norman Maclean Gurdon, J. B. & Melton, D. A. (1981). Gene transfer in amphibian eggs and oocytes. Annu. Rev. Genet. 15, 189-218. Hallerman, E. M. & Kapuscinski, A. R. (1992). Ecological and regulatory uncertainties associated with transgenic fish. In Transgenic Fish, ed. C. L. Hew & G. Fletcher, pp.
Animals with Novel Genes by Norman Maclean